Prediction model for regional or distant recurrence in endometrial cancer based on classical pathological and immunological parameters
Identifieur interne : 002981 ( Main/Exploration ); précédent : 002980; suivant : 002982Prediction model for regional or distant recurrence in endometrial cancer based on classical pathological and immunological parameters
Auteurs : M A Versluis [Pays-Bas] ; R A De Jong [Pays-Bas] ; A. Plat [Pays-Bas] ; T. Bosse [Pays-Bas] ; V T Smit [Pays-Bas] ; H. Mackay [Canada] ; M. Powell [Royaume-Uni] ; A. Leary [France] ; L. Mileshkin [Australie] ; H C Kitchener [Royaume-Uni] ; E J Crosbie [Royaume-Uni] ; R J Edmondson [Royaume-Uni] ; C L Creutzberg [Pays-Bas] ; H. Hollema [Pays-Bas] ; T. Daemen [Pays-Bas] ; G H De Bock [Pays-Bas] ; H W Nijman [Pays-Bas]Source :
- British Journal of Cancer [ 0007-0920 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Facteurs de risque, Femelle, Humains, Lymphocytes T cytotoxiques (immunologie), Modèles de hasards proportionnels, Radiothérapie adjuvante, Récidive tumorale locale (), Récidive tumorale locale (immunologie), Récidive tumorale locale (mortalité), Résultat thérapeutique, Sujet âgé, Survie sans rechute, Tumeurs de l'endomètre (), Tumeurs de l'endomètre (anatomopathologie), Tumeurs de l'endomètre (immunologie), Tumeurs de l'endomètre (mortalité).
- MESH :
- anatomopathologie : Tumeurs de l'endomètre.
- immunologie : Lymphocytes T cytotoxiques, Récidive tumorale locale, Tumeurs de l'endomètre.
- mortalité : Récidive tumorale locale, Tumeurs de l'endomètre.
- Adulte d'âge moyen, Facteurs de risque, Femelle, Humains, Modèles de hasards proportionnels, Radiothérapie adjuvante, Récidive tumorale locale, Résultat thérapeutique, Sujet âgé, Survie sans rechute, Tumeurs de l'endomètre.
English descriptors
- KwdEn :
- Aged, Disease-Free Survival, Endometrial Neoplasms (immunology), Endometrial Neoplasms (mortality), Endometrial Neoplasms (pathology), Endometrial Neoplasms (therapy), Female, Humans, Middle Aged, Neoplasm Recurrence, Local (immunology), Neoplasm Recurrence, Local (mortality), Neoplasm Recurrence, Local (prevention & control), Proportional Hazards Models, Radiotherapy, Adjuvant, Risk Factors, T-Lymphocytes, Cytotoxic (immunology), Treatment Outcome.
- MESH :
- immunology : Endometrial Neoplasms, Neoplasm Recurrence, Local, T-Lymphocytes, Cytotoxic.
- mortality : Endometrial Neoplasms, Neoplasm Recurrence, Local.
- pathology : Endometrial Neoplasms.
- prevention & control : Neoplasm Recurrence, Local.
- therapy : Endometrial Neoplasms.
- Aged, Disease-Free Survival, Female, Humans, Middle Aged, Proportional Hazards Models, Radiotherapy, Adjuvant, Risk Factors, Treatment Outcome.
Abstract
Adjuvant therapy increases disease-free survival in endometrial cancer (EC), but has no impact on overall survival and negatively influences the quality of life. We investigated the discriminatory power of classical and immunological predictors of recurrence in a cohort of EC patients and confirmed the findings in an independent validation cohort.
We reanalysed the data from 355 EC patients and tested our findings in an independent validation cohort of 72 patients with EC. Predictors were selected and Harrell's C-index for concordance was used to determine discriminatory power for disease-free survival in the total group and stratified for histological subtype.
Predictors for recurrence were FIGO stage, lymphovascular space invasion and numbers of cytotoxic and memory T-cells. For high risk cancer, cytotoxic or memory T-cells predicted recurrence as well as a combination of FIGO stage and lymphovascular space invasion (C-index 0.67 and 0.71
In high-risk EC, clinicopathological or immunological variables can predict regional or distant recurrence with equal accuracy, but the use of these variables in combination is more powerful.
Url:
DOI: 10.1038/bjc.2015.268
PubMed: 26217922
PubMed Central: 4559831
Affiliations:
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Mileshkin</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Division of Medical Oncology, Peter MacCallum Cancer Center</institution>, Victoria,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kitchener, H C" sort="Kitchener, H C" uniqKey="Kitchener H" first="H C" last="Kitchener">H C Kitchener</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Department of Gynecology, St Marys Hospital</institution>, Manchester,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Crosbie, E J" sort="Crosbie, E J" uniqKey="Crosbie E" first="E J" last="Crosbie">E J Crosbie</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Department of Gynecology, St Marys Hospital</institution>, Manchester,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Edmondson, R J" sort="Edmondson, R J" uniqKey="Edmondson R" first="R J" last="Edmondson">R J Edmondson</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Department of Gynecology, St Marys Hospital</institution>, Manchester,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Creutzberg, C L" sort="Creutzberg, C L" uniqKey="Creutzberg C" first="C L" last="Creutzberg">C L Creutzberg</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Department of Clinical Oncology, Leiden University Medical Center</institution>, Leiden,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hollema, H" sort="Hollema, H" uniqKey="Hollema H" first="H" last="Hollema">H. 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Daemen</name><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Department of Medical Microbiology, Molecular Virology Section, University of Groningen, University Medical Center Groningen</institution>, Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Bock, G H" sort="De Bock, G H" uniqKey="De Bock G" first="G H" last="De Bock">G H De Bock</name><affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Department of Epidemiology, University of Groningen, University Medical Center Groningen</institution>, Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nijman, H W" sort="Nijman, H W" uniqKey="Nijman H" first="H W" last="Nijman">H W Nijman</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Gynecology, University of Groningen, University Medical Center Groningen</institution>, Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26217922</idno><idno type="pmc">4559831</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559831</idno><idno type="RBID">PMC:4559831</idno><idno type="doi">10.1038/bjc.2015.268</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000707</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000707</idno><idno type="wicri:Area/Pmc/Curation">000706</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000706</idno><idno type="wicri:Area/Pmc/Checkpoint">000D85</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000D85</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002A08</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002A08</idno><idno type="wicri:Area/PubMed/Curation">002938</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002938</idno><idno type="wicri:Area/PubMed/Checkpoint">002938</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002938</idno><idno type="wicri:Area/Ncbi/Merge">002881</idno><idno type="wicri:Area/Ncbi/Curation">002881</idno><idno type="wicri:Area/Ncbi/Checkpoint">002881</idno><idno type="wicri:doubleKey">0007-0920:2015:Versluis M:prediction:model:for</idno><idno type="wicri:Area/Main/Merge">002981</idno><idno type="wicri:Area/Main/Curation">002981</idno><idno type="wicri:Area/Main/Exploration">002981</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Prediction model for regional or distant recurrence in endometrial cancer based on classical pathological and immunological parameters</title><author><name sortKey="Versluis, M A" sort="Versluis, M A" uniqKey="Versluis M" first="M A" last="Versluis">M A Versluis</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Gynecology, University of Groningen, University Medical Center Groningen</institution>, Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Jong, R A" sort="De Jong, R A" uniqKey="De Jong R" first="R A" last="De Jong">R A De Jong</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Radiation Oncology, University of Groningen, University Medical Center Groningen</institution>, Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Plat, A" sort="Plat, A" uniqKey="Plat A" first="A" last="Plat">A. Plat</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Gynecology, University of Groningen, University Medical Center Groningen</institution>, Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bosse, T" sort="Bosse, T" uniqKey="Bosse T" first="T" last="Bosse">T. Bosse</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Pathology, Leiden University Medical Center</institution>, Leiden,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Smit, V T" sort="Smit, V T" uniqKey="Smit V" first="V T" last="Smit">V T Smit</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Pathology, Leiden University Medical Center</institution>, Leiden,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mackay, H" sort="Mackay, H" uniqKey="Mackay H" first="H" last="Mackay">H. Mackay</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Division of Medical Oncology and Hematology, Department of Medicine, University of Toronto</institution>, Toronto,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Powell, M" sort="Powell, M" uniqKey="Powell M" first="M" last="Powell">M. Powell</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Department of Clinical Oncology, Barts Health NHS trust</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Leary, A" sort="Leary, A" uniqKey="Leary A" first="A" last="Leary">A. Leary</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Department of Medicine, Gynecology Unit, Gustave Roussy</institution>, Villejuif,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mileshkin, L" sort="Mileshkin, L" uniqKey="Mileshkin L" first="L" last="Mileshkin">L. Mileshkin</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Division of Medical Oncology, Peter MacCallum Cancer Center</institution>, Victoria,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kitchener, H C" sort="Kitchener, H C" uniqKey="Kitchener H" first="H C" last="Kitchener">H C Kitchener</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Department of Gynecology, St Marys Hospital</institution>, Manchester,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Crosbie, E J" sort="Crosbie, E J" uniqKey="Crosbie E" first="E J" last="Crosbie">E J Crosbie</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Department of Gynecology, St Marys Hospital</institution>, Manchester,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Edmondson, R J" sort="Edmondson, R J" uniqKey="Edmondson R" first="R J" last="Edmondson">R J Edmondson</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Department of Gynecology, St Marys Hospital</institution>, Manchester,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Creutzberg, C L" sort="Creutzberg, C L" uniqKey="Creutzberg C" first="C L" last="Creutzberg">C L Creutzberg</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Department of Clinical Oncology, Leiden University Medical Center</institution>, Leiden,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hollema, H" sort="Hollema, H" uniqKey="Hollema H" first="H" last="Hollema">H. Hollema</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Department of Pathology, University of Groningen, University Medical Center Groningen</institution>, Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Daemen, T" sort="Daemen, T" uniqKey="Daemen T" first="T" last="Daemen">T. Daemen</name><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Department of Medical Microbiology, Molecular Virology Section, University of Groningen, University Medical Center Groningen</institution>, Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Bock, G H" sort="De Bock, G H" uniqKey="De Bock G" first="G H" last="De Bock">G H De Bock</name><affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Department of Epidemiology, University of Groningen, University Medical Center Groningen</institution>, Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nijman, H W" sort="Nijman, H W" uniqKey="Nijman H" first="H W" last="Nijman">H W Nijman</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Gynecology, University of Groningen, University Medical Center Groningen</institution>, Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">British Journal of Cancer</title><idno type="ISSN">0007-0920</idno><idno type="eISSN">1532-1827</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Disease-Free Survival</term><term>Endometrial Neoplasms (immunology)</term><term>Endometrial Neoplasms (mortality)</term><term>Endometrial Neoplasms (pathology)</term><term>Endometrial Neoplasms (therapy)</term><term>Female</term><term>Humans</term><term>Middle Aged</term><term>Neoplasm Recurrence, Local (immunology)</term><term>Neoplasm Recurrence, Local (mortality)</term><term>Neoplasm Recurrence, Local (prevention & control)</term><term>Proportional Hazards Models</term><term>Radiotherapy, Adjuvant</term><term>Risk Factors</term><term>T-Lymphocytes, Cytotoxic (immunology)</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Lymphocytes T cytotoxiques (immunologie)</term><term>Modèles de hasards proportionnels</term><term>Radiothérapie adjuvante</term><term>Récidive tumorale locale ()</term><term>Récidive tumorale locale (immunologie)</term><term>Récidive tumorale locale (mortalité)</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Survie sans rechute</term><term>Tumeurs de l'endomètre ()</term><term>Tumeurs de l'endomètre (anatomopathologie)</term><term>Tumeurs de l'endomètre (immunologie)</term><term>Tumeurs de l'endomètre (mortalité)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs de l'endomètre</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Lymphocytes T cytotoxiques</term><term>Récidive tumorale locale</term><term>Tumeurs de l'endomètre</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Endometrial Neoplasms</term><term>Neoplasm Recurrence, Local</term><term>T-Lymphocytes, Cytotoxic</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Endometrial Neoplasms</term><term>Neoplasm Recurrence, Local</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Récidive tumorale locale</term><term>Tumeurs de l'endomètre</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Endometrial Neoplasms</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Neoplasm Recurrence, Local</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Endometrial Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Disease-Free Survival</term><term>Female</term><term>Humans</term><term>Middle Aged</term><term>Proportional Hazards Models</term><term>Radiotherapy, Adjuvant</term><term>Risk Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Modèles de hasards proportionnels</term><term>Radiothérapie adjuvante</term><term>Récidive tumorale locale</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Survie sans rechute</term><term>Tumeurs de l'endomètre</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background:</title><p>Adjuvant therapy increases disease-free survival in endometrial cancer (EC), but has no impact on overall survival and negatively influences the quality of life. We investigated the discriminatory power of classical and immunological predictors of recurrence in a cohort of EC patients and confirmed the findings in an independent validation cohort.</p></sec><sec><title>Methods:</title><p>We reanalysed the data from 355 EC patients and tested our findings in an independent validation cohort of 72 patients with EC. Predictors were selected and Harrell's C-index for concordance was used to determine discriminatory power for disease-free survival in the total group and stratified for histological subtype.</p></sec><sec><title>Results:</title><p>Predictors for recurrence were FIGO stage, lymphovascular space invasion and numbers of cytotoxic and memory T-cells. For high risk cancer, cytotoxic or memory T-cells predicted recurrence as well as a combination of FIGO stage and lymphovascular space invasion (C-index 0.67 and 0.71 <italic>vs</italic> 0.70). Recurrence was best predicted when FIGO stage, lymphovascular space invasion and numbers of cytotoxic cells were used in combination (C-index 0.82). Findings were confirmed in the validation cohort.</p></sec><sec><title>Conclusions:</title><p>In high-risk EC, clinicopathological or immunological variables can predict regional or distant recurrence with equal accuracy, but the use of these variables in combination is more powerful.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Amant, F" uniqKey="Amant F">F Amant</name></author><author><name sortKey="Cadron, I" uniqKey="Cadron I">I Cadron</name></author><author><name sortKey="Fuso, L" uniqKey="Fuso L">L Fuso</name></author><author><name sortKey="Berteloot, P" uniqKey="Berteloot P">P Berteloot</name></author><author><name sortKey="De Jonge, E" uniqKey="De Jonge E">E de Jonge</name></author><author><name sortKey="Jacomen, G" uniqKey="Jacomen G">G Jacomen</name></author><author><name sortKey="Van Robaeys, J" uniqKey="Van Robaeys J">J Van Robaeys</name></author><author><name sortKey="Neven, P" uniqKey="Neven P">P 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uniqKey="Fujiwara K">K Fujiwara</name></author><author><name sortKey="Herzog, Tj" uniqKey="Herzog T">TJ Herzog</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>Canada</li><li>France</li><li>Pays-Bas</li><li>Royaume-Uni</li></country></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Versluis, M A" sort="Versluis, M A" uniqKey="Versluis M" first="M A" last="Versluis">M A Versluis</name></noRegion><name sortKey="Bosse, T" sort="Bosse, T" uniqKey="Bosse T" first="T" last="Bosse">T. Bosse</name><name sortKey="Creutzberg, C L" sort="Creutzberg, C L" uniqKey="Creutzberg C" first="C L" last="Creutzberg">C L Creutzberg</name><name sortKey="Daemen, T" sort="Daemen, T" uniqKey="Daemen T" first="T" last="Daemen">T. Daemen</name><name sortKey="De Bock, G H" sort="De Bock, G H" uniqKey="De Bock G" first="G H" last="De Bock">G H De Bock</name><name sortKey="De Jong, R A" sort="De Jong, R A" uniqKey="De Jong R" first="R A" last="De Jong">R A De Jong</name><name sortKey="Hollema, H" sort="Hollema, H" uniqKey="Hollema H" first="H" last="Hollema">H. Hollema</name><name sortKey="Nijman, H W" sort="Nijman, H W" uniqKey="Nijman H" first="H W" last="Nijman">H W Nijman</name><name sortKey="Plat, A" sort="Plat, A" uniqKey="Plat A" first="A" last="Plat">A. Plat</name><name sortKey="Smit, V T" sort="Smit, V T" uniqKey="Smit V" first="V T" last="Smit">V T Smit</name></country><country name="Canada"><noRegion><name sortKey="Mackay, H" sort="Mackay, H" uniqKey="Mackay H" first="H" last="Mackay">H. Mackay</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Powell, M" sort="Powell, M" uniqKey="Powell M" first="M" last="Powell">M. Powell</name></noRegion><name sortKey="Crosbie, E J" sort="Crosbie, E J" uniqKey="Crosbie E" first="E J" last="Crosbie">E J Crosbie</name><name sortKey="Edmondson, R J" sort="Edmondson, R J" uniqKey="Edmondson R" first="R J" last="Edmondson">R J Edmondson</name><name sortKey="Kitchener, H C" sort="Kitchener, H C" uniqKey="Kitchener H" first="H C" last="Kitchener">H C Kitchener</name></country><country name="France"><noRegion><name sortKey="Leary, A" sort="Leary, A" uniqKey="Leary A" first="A" last="Leary">A. Leary</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Mileshkin, L" sort="Mileshkin, L" uniqKey="Mileshkin L" first="L" last="Mileshkin">L. Mileshkin</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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